Yeast Genetics and Molecular Biology Group   
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Dr. Oksana Tehlivets (Junior Group Leader)

contact
e-Mail: oksana.tehlivets@uni-graz.at
phone: +43 (316) 380 - 5504
web: http://yeast.uni-graz.at

research topics
Lipid metabolism, phospholipid methylation and unsaturated fatty acid metabolism in yeast
Coordination of lipid biosynthesis with other cellular processes in yeast e.g. AdoMet-dependent methylation and unfolded protein response
Toxicity of S-adenosyl-L-homocysteine and homocysteine, S-adenosyl-L-homocysteine hydrolase

past and current projects
Molecular mechanisms of S-adenosyl-L-homocysteine toxicity (FWF P-24216)
Coordination of methylation and lipid biosynthesis (FWF P-18094)

curriculum vitae
Studies of Biochemistry at the Lviv State University, Lviv, Ukraine (1987-1992); Diploma 1992
Researcher at the Institute of Biochemistry, Academy of Sciences of Ukraine, Lviv, Ukraine (1992-1995)
OÄD stipend at the Graz University of Technology (1993)
PhD at Karl-Franzens University Graz (1999)
Postdoctoral fellow at Karl-Franzens University Graz (1999-2005)
Research stay at Cornell University,Ithaca, USA (2004)
Junior group leader, Institute of Molecular Biosciences, University of Graz (since 2005)

publications
Tehlivets, O., Malanovic, N., Visram, M., Pavkov-Keller, T., Keller, W. (2013) S-adenosyl-L-homocysteine hydrolase and methylation disorders: Yeast as a model system. Biochim Biophys Acta 1832(1), 204-15.

Tehlivets, O. (2012) Homocysteine as a risk factor for atherosclerosis: is its conversion to s-adenosyl-L-homocysteine the key to deregulated lipid metabolism? J Lipids, 2011:702853.

Malanovic, N., Streith, I., Wolinski, H., Rechberger, G., Kohlwein, S.D. and Tehlivets, O. (2008) S-adenosyl-L-homocysteine hydrolase, key enzyme of methylation metabolism, regulates phosphatidylcholine synthesis and triacylglycerol homeostasis in yeast: implications for homocysteine as a risk factor of atherosclerosis. J Biol Chem 283(35), 23989-99.

Cipak, A., Jaganjac, M., Tehlivets, O., Kohlwein, S.D. and Zarkovic, N. (2008) Adaptation to oxidative stress induced by polyunsaturated fatty acids in yeast. Biochim Biophys Acta 1781(6-7), 283-7.

Tehlivets, O, K. Scheuringer, and S.D. Kohlwein. (2007) Fatty acid synthesis and elongation in yeast. (invited review) Biochim. Biophys. Acta - Mol. Cell. Biol. Lipids, 1771(3):255-70

Cipak, A., M. Hasslacher, O. Tehlivets, E. J. Collinson, M. Zivkovic, T. Matijevic, W. Wonisch, G. Waeg, I. W. Dawes, N. Zarkovic, and S. D. Kohlwein (2006) Saccharomyces cerevisiae strain expressing a plant fatty acid desaturase produces polyunsaturated fatty acids and is susceptible to oxidative stress induced by lipid peroxidation. Free Radic. Biol. Med. 40(5), 897-906

Tehlivets, O., Hasslacher, M. and Kohlwein, S.D. (2004) S-adenosyl-L-homocysteine hydrolase in yeast: key enzyme of methylation metabolism and coordinated regulation with phospholipid synthesis. FEBS Lett. 577/3, 501-6

Shirra, M.K., Patton-Vogt, J., Ulrich, A., Liuta-Tehlivets, O., Kohlwein, S.D., Henry S.A. and Arndt, K.M. (2001) Inhibition of acetyl coenzyme A carboxylase activity restores expression of the INO1 gene in a snf1 mutant strain of Saccharomyces cerevisiae. Mol. Cell. Biol. 21, 5710-22.

Boretsky, Y., Voronovsky, A., Liuta-Tehlivets, O., Hasslacher, M., Kohlwein, S.D., and Shavlovsky, G.M. (1999) Identification of an ARS element and development of a high efficiency transformation system for Pichia guilliermondii. Curr. Genet. 36, 215-221.

Boretska, N.I., Liauta-Teglivets, O.Ye., Voronovsky, A.Ya., Boretsky, Yu.R. and Shavlovsky, G.M. (1996) [Mapping of the region of Bacillus subtilis riboflavin operon determining 3,4-dihydroxy-2-butanon-4-phosphate synthetase activity.] Biopolimeri i kletka, V. 12, N. 1, P. 1-5. (Russian)

Liauta-Teglivets, O., Hasslacher, M., Boretsky, Yu.R., Kohlwein, S.D. and Shavlovsky, G.M. (1995) Molecular cloning of the GTP-cyclohydrolase structural gene RIB1 of Pichia guilliermondii involved in riboflavin biosynthesis. Yeast 11, 945-952.

 




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